Klinik und Poliklinik für Neurologie
 Universitätsmedizin Leipzig
Fotograf: Stefan Straube

Language & Aphasia Lab

Contact
Members
Grants
Cooperation partners
Doctoral students
Alumni
Labmeeting
Research interests
Methods
Publications

Contact

Research group office
Ines Kunis
House 4, Room G1074
Liebigstraße 20, 04103 Leipzig
📞 +49 341 97-24243

Language and Aphasia group photo 2016 Plus Symbol Language And Aphasia Lab

Members

Professorin Dr. med. Dorothee Saur
Professor Dr. med. Dorothee Saur
Group leader
Phone 0341 97-24243, (-24197)
Mail dorothee.saur@medizin.uni-leipzig.de
Room G 1008
CV CV.pdf (PDF 45 kB)

klingbeil
Julian Klingbeil
Postdoc
Phone 0341 97-24215(-24243)
Mail julian.klingbeil@medizin.uni-leipzig.de
Room Room 143 „Carl Wernicke“ – Haus am Park
CV CV.pdf (PDF 35 kB)

stockert
Anika Stockert
Postdoc
Phone 0341 97-24215(-24243)
Mail anika.stockert@medizin.uni-leipzig.de
Room Room 143 „Carl Wernicke“ – Haus am Park
CV CV.pdf (PDF 160 kB)

Max Wawrzyniak
Max Wawrzyniak

Phone 0341 97-24215(-24243)
Mail max.wawrzyniak@medizin.uni-leipzig.de
Room Raum 143 „Carl Wernicke“ – Haus am Park
CV CV.pdf (PDF 34 kB)

Foto
Dr. med. Dipl. Psych. Mandy Pirlich
Postdoc
Phone 0341 97-24243
Mail mandy.pirlich@medizin.uni-leipzig.de

Ines Zimmermann
Ines Kunis
Speech & language therapist
Phone 0341 97-24243
Mail ines.kunis@medizin.uni-leipzig.de

Melanie Schindhelm
Melanie Schindhelm
Speech & language therapist
Phone 0341 97-24243
Mail melanie.schindhelm@medizin.uni-leipzig.de

Student assistants

Hans Schneider, cand. med.
Mail: hansralf.schneider@medizin.uni-leipzig.de

Steven Kalinke
Mail: steven.kalinke@medizin.uni-leipzig.de

Grants

James S. McDonnell Foundation (JSMF): "Funktion, Dysfunktion und Erholung von Sprachnetzwerken". 1/2012-12/2017 (Dorothee Saur)
http://www.jsmf.org/grants/20112027/

Cooperation partners

Dr. Gesa Hartwigsen, group leader at Max-Planck-Institut für Kognitions- und Neurowissenschaften

Doctoral Students

Cathleen Höfer, cand. med.
Mail: cathleen_hoefer@gmx.de
PhD thesis: Brain volumetric measurement and collection of verbal and spatial memory performance of patients with transient global amnesia - a prospective study

Sophia Hormig, cand. med.
Mail: sophia.hormig@web.de
PhD thesis: pathology of network lesions of the thalamus

Susann Machleb, cand. med.
Mail: susann.machleb@medizin.uni-leipzig.de
PhD thesis: Disturbance awareness of patients with aphasia: Course observation and neuronal correlations

Anni Weigel, cand. med.
Mail: anniweigel@rocketmail.com
PhD thesis: Contribution of frontal and parietal brain regions to semantic and phonological decissions: A TMS study

Christin Wendt, cand. med.
Mail: christin.wendt@medizin.uni-leipzig.de
PhD thesis: Temporo-frontal interactionsat semantic integration: A fMRT-TMS study
(in cooperation with Dr. Ilona Henseler, MPI for cognitive and neuronal science)

Alumni

Dr. rer. med. Katrin Wrede
Former postdoc of the research group
As of October 2015 leading speech and language therapist at the St. Mauritius therapeutic clinik in Meerbusch.

Dr. med. Thomas Golombek
Project: role of the left angular gyrus in auditive speech comprehension
(in cooperation with the Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig)
PhD thesis defense: 05.02.2015

Dr. med. Maren Klein
Project: Modulating phonological and sematic processes in the language network: a combined TMS and fMRI study
PhD thesis defense: 26.03.2015

Labmeeting

Wednesday, 6:30 pm; room G1024 together with Claßen-Lab

Research Interests

Multimodal investigations of language networks in healthy subjects and patients with aphasia after stroke

  • Intra- and interhemispheric language networks for different linguistic functions (e.g. semantics, phonology) 
  • Adaptive reorganisation in language networks after focal virtual lesions induced with non-invasive brain stimulation
  • Longitudinal investigation of language recovery after stroke

Methods

  • functional magnetic resonance imaging (fMRI) and resting state fMRI 
  • diffusion tensor imaging (DTI) fMRT Plus Symbol
  • voxel-based behavior lesion symptom mapping (VBLSM) 
  • multifocal (repetitive) transcranial magnetic stimulation ((r)TMS) 
  • electroencephalography (EEG) 
  • simultaneous EEG-fMRI

Publications

2016

Demuth HU, ... Saur D, ... Boltze J. Recent progress in translational research on neurovascular and neurodegenerative disorders. Restorative Neurology and Neurosciences, in press.

Hartwigsen G, Henseler I, Stockert A, Wawrzyniak M, Wendt C, Klingbeil J, Baumgärtner A, Saur D. Integration demands modulate effective connectivity in a front-temporal network for contextual sentence integration. NeuroImage, in press.

Pelz JO, Weinreich A, Karlas T, Saur D. Evaluation of freehand B-mode and power-mode 3D ultrasound for visualisation and grading of internal carotid stenosis. PLOS ONE, in press.

Martin M, Dressing A, Bormann T, Schmidt C, Kümmerer D, Beume LA, Saur D, Mader I, Rijntjes M, Kaller C, Weiller C. A componential network for the recognition of tool-associated actions: Evidence from voxel-based lesion-symptom mapping in acute stroke patients. Cereb Cortex, in press.

Hamzei F, Vry M-S, Saur D, Glauche V, Hoeren M, Mader I, Weiller C, Rijntjes M. (2016) The dual loop model and the human mirror neuron system: an exploratory combined fMRI and DTI study of the inferior frontal gyrus. Cereb Cortex 26(5): 2215-2224.

Saur D. (2016) Commentary on Bajada et al. (2015) Cortex, Volume 75, February 2016, Pages 247–248. doi:10.1016/j.cortex.2015.06.004. Discussion on Transport for language south of the Sylvian fissure: The routes and history of the main tracts and stations in the ventral language network. Cortex. 2015 Aug;69:141-51. doi: 10.1016/j.cortex.2015.05.011. Epub 2015 May 19.

Stockert A, Kümmerer D, Saur DInsights into early language recovery: from basic principles to practical applications. Aphasiology, Volume 30, Issue 5, 2016.

Werner, P., Saur D, et al. (2016). Combined PET/MRI: Multimodality insights into acute stroke hemodynamics. Neurology 86(20): 1926-1927.

2015

Hartwigsen GWeigel A, Schuschan P, Siebner HR, Weise D, Classen J, Saur DDissociating Parieto-Frontal Networks for Phonological and Semantic Word Decisions: A Condition-and-Perturb TMS Study.  Cereb Cortex 26(6): 2590-2601.

Pelz J, Weinreich A, Fritzsch D, Saur DQuantification of Internal Carotid Artery Stenosis with 3D Ultrasound Angiography.  Ultraschall in Med 2015; 36:1-7.

Pelz J, Fricke C,  Saur D., Classen J. Failure to confirm benefit of acetyl-DL-leucine in degenerativ cerebellar ataxie. A case series. Letter in J Neurol, 2015, 262(5):1373-1375.

Schwartze M, Stockert A, Kotz SA (2015). Striatal contributions to sensory timing: Voxel-based lesion mapping of electrophysiological markers. Cortex. 2015 Oct;71:332-340. doi: 10.1016/j.cortex.2015.07.016. Epub 2015 Aug 4. PubMed PMID: 26298502.

Werner P, Saur D., et al. (2015). Simultaneous PET/MRI in stroke: A case series. J Cereb Blood Flow Metab 35(9): 1421-1425.

2014

Kotz SA, Stockert A, Schwartze M (2014). Cerebellum, temporal predictability and the updating of a mental model. Philos Trans R Soc Lond B Biol Sci. 2014 Dec 19;369(1658):20130403. doi: 10.1098/rstb.2013.0403. PubMed PMID: 25385781.

Suchan J, Umarova R, Schnell S, Himmelbach M, Weiller C, Karnath HO, Saur D (2014). Fiber pathways connecting cortical areas relevant for spatial orienting and exploration. Hum Brain Mapp: 35(3): 1031-1043.

2013

Baumgaertner A, Hartwigsen G, Siebner HR (2013). Right-hemispheric processing of non-linguistic word features: implications for mapping language recovery after stroke. Hum Brain Mapp 34(6): 1293-1305.

Meinzer M, Beeson PM, Cappa S, Crinion J, Kiran S, Saur D, Parrish T, Crosson B, Thompson CK (2013). Neuroimaging in aphasia treatment research: Consensus and practical guidelines for data analysis. Neuroimage 73: 215-224.

Hartwigsen GSaur D, Price CJ, Baumgaertner A, Ulmer S, Siebner HR (2013). Increased excitatory connectivity from the pre-supplementary motor area to the left dorsal premotor cortex during pseudoword repetition. J Cogn Neurosci 25(4):580-594.

Hartwigsen GSaur D, Price CJ, Ulmer S, Baumgaertner A, Siebner HR (2013). Perturbation of left posterior inferior frontal gyrus triggers adaptive plasticity in the right homologue during speech production. Proc Natl Acad Sci U S A 110(41): 16402-16407.

Kellmeyer P, Ziegler W, Peschke C, Eisenberger J, Schnell S, Baumgaertner A, Weiller C, Saur D (2013). Fronto-parietal dorsal and ventral pathways in the context of different linguistic manipulations. Brain & Language 127(2): 241-250.

Kümmerer D, Hartwigsen G, Kellmeyer P, Glauche V, Mader I, Klöppel S, Suchan J, Karnath HO, Weiller C, Saur D (2013). Damage to ventral and dorsal language pathways in acute aphasia. Brain 2: 619-629.

Reiche M, Hartwigsen G, Widmann A, Saur D, Schröger E, Bendixen A (2013). Involuntary attentional capture by speech and non-speech deviations: A combined behavioral-event-related potential study. Brain Res 1490: 153-160.

2012

Hartwigsen G, Bestmann S, Ward NS, Woerbel S, Mastroeni C, Granert O, Siebner HR (2012). Left dorsal premotor cortex and supramarginal gyrus complement each other during rapid action reprogramming. J Neurosci 32(46):16162-16171.

Hartwigsen G, Siebner HR (2012). Probing the involvement of the right hemisphere in language processing with online transcranial magnetic stimulation in healthy volunteers. Review. Aphasiology 26(9):1131-1152.

den Ouden DB, Saur D, Mader W, Schelter B, Lukic S, Wali E, et al. (2012). Network modulation during complex syntactic processing. Neuroimage 59(1):815-23.

Pechmann A, Delvendahl I, Bergmann TO, Ritter C, Hartwigsen G, Gleich B, Gattinger N, Mall V, Siebner HR (2012). The number of full-sine cycles per pulse influences the efficacy of multi-cycle transcranial magnetic stimulation. Brain Stimul 5(2): 148-154.

Rijntjes M, Hamzei F, Glauche V, Saur D, Weiller C (2012). Activation changes in sensorimotor cortex during improvement due to CIMT in chronic stroke. Restor Neurol Neurosci. 29(5):299-310.

Saur DHartwigsen G (2012). Neurobiology of language recovery after stroke: lessons from neuroimaging studies. Review. Arch Phys Med Rehabil 93(1) Supp1: S15-S25.

Vry M, Saur D, Rijntjes M, Umarova R, Kellmeyer P, Schnell S, Glauche V, Hamzei F, Weiller C (2012). Ventral and dorsal fibre systems for imaged and executed movement. Exp Brain Res 219(2): 203-216.

2011

Umarova RM, Saur D, Kaller CP, Vry MS, Glauche V, Mader I, et al. (2011). Acute visual neglect and extinction: distinct functional state of the visuospatial attention system. Brain 134(Pt 11):3310-25.

Weiller C, Bormann T, Saur D, Musso M, Rijntjes M. (2011). How the ventral pathway got lost: and what its recovery might mean. Brain Lang. 118(1-2):29-39.

Zeller D, Dang SY, Stefan K, Biller A, Bartsch A, Saur D, Bendszus M, Rieckmann P, Toyka KV, Classen J (2011). Functional role of ipsilateral motor areas in multiple sclerosis. J Neurol Neurosurg Psychiatry. 82: 578-583.

2010

Dressel K, Huber W, Frings L, Kümmerer D, Saur D, Mader I, Hüll M, Weiller C, Abel S (2010). Model-oriented naming therapy in semantic dementia: A single-case fMRI study. Aphasiology  24: 1464-5041.

Frings L, Dressel K, Abel S, Saur D, Kümmerer D, Mader I, Weiller C, Hüll M. (2010). Reduced Precuneus Deactivation during Object Naming in Patients with Mild Cognitive Impairment, Alzheimer's Disease, and Frontotemporal Lobar Degeneration. Dement Geriatr Cogn Disord 30(4): 334-343.

Hartwigsen G, Siebner HR, Stippich C (2010). Preoperative functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS). Curr Med Imaging Rev. 2010; 6(4):220-231.

Hartwigsen G, Baumgaertner A, Price CJ, Koehnke M, Ulmer S, Siebner HR (2010). Efficient phonological decisions require both the left and right supramarginal gyri. Proc Natl Acad Sci U S A 107:16494-16499.

Hartwigsen G, Price CJ, Baumgaertner A, Geiss G, Koehnke M, Ulmer S, Siebner HR (2010). The right posterior inferior frontal gyrus contributes to phonological word decisions in the healthy brain: Evidence from dual-site TMS. Neuropsychologia 48:3155-3163.

Hartwigsen G, Siebner HR, Deuschl G, Jansen O, Ulmer, S (2010). Incidental findings are frequent in young healthy individuals undergoing MRI in brain research imaging studies: a prospective single center study. JCAT 34(4):596-600.

Rüsch N, Bracht T, Kreher BW, Schnell S, Glauche V, Il'yasov KA, Ebert D, Lieb K, Hennig J, Saur D, van Elst LT (2010). Reduced interhemispheric structural connectivity between anterior cingulate cortices in borderline personality disorder . Psychiatry Res 181(2):151-4.

Saur D, Ronneberger O, Kümmerer D, Mader I, Weiller C, Klöppel, S (2010). Early fMRI activations predict language outcome after stroke. Brain 133:1252-1264.

Saur D, Schelter B, Schnell S, Kratochvil D, Küpper H, Kellmeyer P, Kümmerer D, Klöppel S, Glauche V, Lange R, Mader W, Feess D, Timmer J, Weiller C (2010). Combining functional and anatomical connectivity reveals brain networks for auditory comprehension. NeuroImage 49:3187-3197.

Saur D (2010). [Imaging aphasia]. Nervenarzt 81(12),1429-37.

Ulmer S, Hartwigsen G, Riedel C, Jansen O, Mehdorn HM, Nabavi A (2010).Intraoperative dynamic susceptibility contrast MRI (iDSC-MRI) is as reliable as preoperatively acquired perfusion mapping. NeuroImage 49(3), 2158-2162.

Umarova R, Saur D, Schnell S, Kaller C, Vry MS, Glauche V, Rijntjes M, Kiselev V, Weiller C (2010). Structural Connectivity for Visuospatial Attention. Significance of Ventral Pathways. Cereb Cortex 20: 121-129.

Ward NS, Bestmann S, Hartwigsen G, Weiss M, Christensen L, Frackowiak R, Rothwell JC, Siebner HR (2010). Low-frequency transcranial magnetic stimulation of left dorsal premotor cortex improves the dynamic control of visuospatially cued actions. J Neurosci 30(27), 9216-9223.

2009

Abel S, Dressel K, Kümmerer D, Saur D, Mader I, Weiller C, Huber W (2009). Correct and erroneous picture naming responses in healthy subjects. Neurosci Lett. 2009 463(3):167-71.

Altamura C, Reinhard M, Vry MS, Kaller CP, Hamzei F, Vernieri F, Rossini PM, Hetzel A, Weiller C, Saur D (2009). The longitudinal changes of BOLD response and cerebral hemodynamics from acute to subacute stroke. A fMRI and TCD study. BMC Neurosci 10:151.

Bracht T, Tüscher O, Schnell S, Kreher B, Rüsch N, Glauche V, Lieb K, Ebert D, Il'yasov KA, Hennig J, Weiller C, van Elst LT, Saur D (2009). Extraction of prefronto-amygdalar pathways by combining probability maps. Psychiatry Res 174(3):217-22.

Saur D, Baumgaertner A, Moehring A, Buechel C, Bonnesen M, Rose M, Musso M, Meisel JM (2009). Word order processing in the bilingual brain. Neuropsychologia 47: 158-168.

Schnell S, Saur D, Kreher BW, Hennig J, Burkhardt H, Kiselev VG (2009). Fully automated classification of HARDI in vivo data using a support vector machine. Neuroimage 46(3):642-51.

Siebner HR, Hartwigsen G, Kassuba T, Rothwell JC (2009).How does transcranial magnetic stimulation modify neuronal activity in the brain? -Implications for studies of cognition. Cortex 45(9),1035-1042.

Weiller C, Musso M, Rijntjes M, Saur D (2009).Please don’t underestimate the ventral pathway in language. Letter in Trends Cogn Sci 13(9): 369-370.

bis 2008

Kreher BW, Schnell S, Mader I, Il'yasov KA, Hennig J, Kiselev VG, Saur D (2008). Connecting and Merging Fibres: Pathway Extraction by Combining Probability Maps. NeuroImage 43: 81-89.

Mader W, Feess D, Lange R, Saur D, Glauche V, Weiller C, Timmer J, Schelter B (2008). On the detection of direct directed information flow in fMRI. IEEE Journal of selected topics in signal processing 2:965-974.

Saur D, Buchert R, Knab R, Weiller C, Rother J (2006). Iomazenil-single-photon emission computed tomography reveals selective neuronal loss in magnetic resonance-defined mismatch areas. Stroke 37:2713-2719.

Saur D, Kreher BW, Schnell S, Kümmerer D, Kellmeyer P, Vry M-S, Umarova R, Musso M, Glauche V, Abel S, Huber W, Rijntjes M, Hennig J, Weiller C (2008). Ventral and dorsal pathways for language. Proc Natl Acad Sci U S A 105(45):18035-18040.

see also: Saur D, Kellmeyer P, Weiller C. Replay to Yamada: The extreme capsule is the ventral pathway for language. Letter in Proc Natl Acad Sci U S A 2009; 106(7): E15.

Saur D, Kucinski T, Grzyska U, Eckert B, Eggers C, Niesen W, Schoder V, Zeumer H, Weiller C, Röther J. Sensitivity and interrater agreement of CT and diffusion-weighted MR imaging in hyperacute stroke. AJNR Am J Neuroradiol. 2003 May;24(5):878-85.

see also: Saur D, Roether J. Replay to Pexman et al.: Experience Does Not Prevent Misinterpretation of Native CT Scans. MR imaging in hyperacute stroke. AJNR Am J Neuroradiol 2004; 25:516-518.

Saur D, Lange R, Baumgaertner A, Schraknepper V, Willmes K, Rijntjes M, Weiller C (2006). Dynamics of language reorganization after stroke. Brain 129:1371-1384.

Book chapters

Saur DHartwigsen G (2011). Funktionsanpassung im sprachlichen System. In: Karnath, H.-O. & Thier, H.-P. (Eds.), Kognitive Neurowissenschaften, 3. Auflage, Kapitel 68. Heidelberg: Springer.

Saur D, Weiller C. Recovery from aphasia: lessons from imaging studies (2010). In: SC Cramer & RJ Nudo (Eds.). Brain Repair after Stroke. 1st Ed. Cambridge University Press (Cambridge, England).

Hartwigsen G, Kassuba T, Siebner HR (2009). Combining transcranial magnetic stimulation with (f)MRI. In: S ulmer & O Jansen (Eds.). fMRI: Basics and clinical applications. 1st Ed. Springer (Heidelberg, Germany). pp 155-167.

Saur D, Weiller C (2009). Bildgebende Verfahren. Aktivierungsstudien mit fMRT und PET. In: W Sturm, M Herrmann, TF Münte (Hrsg.), Lehrbuch der Klinischen Neuropsychologie, 2. Auflage. Spektrum Akademischer Verlag.

 
Letzte Änderung: 19.12.2016, 20:35 Uhr | Redakteur: Dorothee
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Klinik und Poliklinik für Neurologie